Soluble CD44 is a promising biomarker has a prognostic value in breast cancer patients

Background: Cancer is a heterogeneous disease encompassing various subtypes. Exploration of novel biomarkers important to tailor therapy. Aim: The main aim this study was toexplore the prognostic value soluble CD44 in sera breast cancer patients (BCPs), and correlate its levels with hyaluronic acid (HA), VEGF p53 levels. Subjects Methods: Fifty female BCPs were enrolled as patient group 50 healthy females control group. Cancerous neighboring normal tissues collected from BCPs. Blood samples at diagnosis tissue expression evaluated by immunohistochemistry (IHC). Serum sCD44, HA, VEGF, p53levels measured ELISA. Results: showed high cancerous compared tissues. Circulating sCD44 highly increased associated significantly HA elevated along increase positivity. In contrast, decrease level higher According Kaplan-Meier curves, who expressed of  or shorter DFS time than negative. Conclusion: Tissue are increases VEGF.  Increased related bad patients' survival. As such, can be used marker patients.